Visualising genetic distance information from personal genetics sites

What is gene visualization?

A visualization can consist of one or multiple views displaying features mapped to genomic coordinates, which can be linked or independent. A genome can be very large and analyzing it on different scales, such as the whole genome or single genes, can be of great value.

What is a circos plot?

Chromosome-based circos plots are the ones that can take a lot of different types of data, as long as all the data points know which chromosomes they are on and what their positions are within those chromosomes. Chromosome-based circos plot from R circlize package examples.

Why is visualization so important in genetic genomic research and analysis?

Visualisation plays an essential role in genomics research by making it possible to observe correlations and trends in large datasets as well as communicate findings to others.

What is personal genetic data?

Genetic data is personal data relating to inherited or acquired genetic characteristics of a natural person acquired through DNA or RNA analysis. Genetic samples are some of the most sensitive forms of personal data, and contain vast amounts of unique, both health and non-health-related information.

What is differential gene expression analysis?

Differential expression analysis means taking the normalised read count data and performing statistical analysis to discover quantitative changes in expression levels between experimental groups.

What is a fusion mutation?

Gene fusions, or translocations, resulting from chromosomal rearrangements are the most common mutation class. They lead to chimeric transcripts or to deregulation of genes through juxtapositioning of novel promoter or enhancer regions.

What does a Manhattan plot show?

Manhattan plots represent the P values of the entire GWAS on a genomic scale (Fig. 2a). The P values are represented in genomic order by chromosome and position on the chromosome (x-axis). The value on the y-axis represents the −log10 of the P value (equivalent to the number of zeros after the decimal point plus one).

What is synteny and how do we use it in genomics and genetics?

In classical genetics, syntenic genes were originally defined as genes that lie on the same chromosome. Today, however, biologists usually refer to synteny as the conservation of blocks of order within two sets of chromosomes that are being compared with each other.

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